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Acute and chronic adverse effects of cannabis use

Acute adverse effects

  • Anxiety and panic, especially in naive users
  • Psychotic symptoms (at high doses)
  • Road crashes if a person drives while intoxicated

Chronic adverse effects

  • Cannabis dependence syndrome (in around one in ten users)
  • Chronic bronchitis and impaired respiratory function in regular smokers
  • Psychotic symptoms and disorders in heavy users, especially those with a history of psychotic symptoms or a family history of these disorders
  • Impaired educational attainment in adolescents who are regular users
  • Subtle cognitive impairment in those who are daily users for 10 years or more

Possible adverse effects of regular cannabis use with unknown causal relation

  • Respiratory cancers
  • Behavioral disorders in children whose mothers used cannabis while pregnant
  • Depressive disorders, mania, and suicide
  • Use of other illicit drugs by adolescents

Source: Review | www.thelancet.com | Vol 374 October 17, 2009
Adverse health effects of non-medical cannabis Use by Wayne Hall, Louisa Degenhardt

For over two decades, cannabis, commonly known as marijuana, has been the most widely used illicit drug by young people in high-income countries, and has recently become popular on a global scale. Epidemiological research during the past 10 years suggests that regular use of cannabis during adolescence and into adulthood can have adverse effects. Epidemiological, clinical, and laboratory studies have established an association between cannabis use and adverse outcomes. We focus on adverse health effects of greatest potential public health interest—that is, those that are most likely to occur and to affect a large number of cannabis users. The most probable adverse effects include a
dependence syndrome, increased risk of motor vehicle crashes, impaired respiratory function, cardiovascular disease, and adverse effects of regular use on adolescent psychosocial development and mental health.

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