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August 25th, 2018

Dosing For Therapeutic Benefit and Minimal Psychoactivity

Information obtained from a limited number of small and short-term clinical studies of cannabis for medical purposes indicate the daily doses of smoked or vapourized dried cannabis ranged from as little as 75 mg of dried cannabis 9.4% THC by weight) (i.e. 7 mg THC/day) to a maximum of 3.2 grams of dried cannabis (1–8% THC by weight; i.e. 32 to 256 mg THC).

Doses of THC as low as 2.5–3 mg of THC (and even lower) are associated with a therapeutic benefit and minimal psychoactivity.

Various surveys published in the peer-reviewed scientific and medical literature have suggested that the majority of people using smoked or orally ingested cannabis for medical purposes reported using between 10–20 grams of cannabis per week, or approximately 1–3 grams of dried cannabis per day.

One study reported the average daily dose of dried cannabis (of various potencies) used by patients in the Netherlands’ Medical Cannabis program was 0.68 grams per day (range: 0.65 –0.82 grams per day).

Another study suggests that regardless of route of administration (inhalation vs. oral), individuals reporting use of cannabis for medical purposes reported consuming equivalent amounts of cannabis per day and that amount averaged at around 3 grams per day.

  • For smoking and vapourizing, the median reported dose was 1.5–2.0 grams per day respectively.
  • For edibles, the median reported dose was 1.5 grams per day.
  • For teas, the median reported dose was 1.5 grams per day.

There is no information available on dosing amounts for topically applied cannabis products (e.g. ointments, creams, lotions, oils, balms, salves), however one study suggests approximately 5% of individuals who use marijuana for medical purposes use such products.

There is no information available on dosing amounts for fresh marijuana.

In the absence of any clinical studies conducted with cannabis products, such as oils that are ingested orally, the following information has been provided as a reference to give some potential guidance around dosing.

For products such as oils that are ingested orally

  • The available clinical evidence for Marinol®, an orally administered capsule that has received market authorization and that contains synthetic THC dissolved in sesame oil, indicates a dosing range from as low as 2.5 mg THC per day to a maximum dose of 210 mg THC per day.
  • Doses lower than 2.5 mg (e.g. 1 mg) THC may further avoid incidence and risks of adverse effects.
  • Average dose of Marinol® is 20 mg THC per day.
  • Maximal recommended daily oral dose of Marinol® is 40 mg per day.
  • Preliminary information from an open-label clinical trial with Epidiolex® (an orally administered oil extract containing mainly cannabidiol (CBD) for treatment of certain types of childhood epilepsy not responsive to conventional treatment), suggests a daily dosing range between 5 and 20 mg/kg CBD.However, further clinical studies are required to substantiate this information.

Data Source: Access to Cannabis for Medical Purposes Regulations – Daily Amount Fact Sheet (Dosage) – Canada.ca https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/information-medical-practitioners/cannabis-medical-purposes-regulations-daily-amount-fact-sheet-dosage.html

Canna Crocker Guide to Micro-dosing

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AuthorCanna Crocker
BindingKindle Edition
EISBN9781983403958
FormatKindle eBook
LanguagesName: English; Type: Published
Number Of Pages93
Product GroupeBooks
Product Type NameABIS_EBOOKS
Publication Date2018-01-02
Release Date2018-01-02
TitleCanna Crocker Guide to Micro-dosing

Microdosing: Enhance your Vitality, Temperament and Efficiency with Hallucinogenic

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as of May 20, 2019 12:59 pm

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AuthorN Kumar
BindingPaperback
EAN9781533112293
EAN ListEAN List Element: 9781533112293
ISBN1533112290
Item DimensionsHeight: 900; Length: 600; Weight: 22; Width: 14
LabelCreateSpace Independent Publishing Platform
ManufacturerCreateSpace Independent Publishing Platform
Number Of Pages58
Package DimensionsHeight: 14; Length: 900; Weight: 31; Width: 600
Product GroupBook
Product Type NameABIS_BOOK
Publication Date2016-05-05
PublisherCreateSpace Independent Publishing Platform
StudioCreateSpace Independent Publishing Platform
TitleMicrodosing: Enhance your Vitality, Temperament and Efficiency with Hallucinogenic

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